From the end of the XX century academic community has been extensively discussing globalization issues affecting economy, politics and culture. First and foremost there grew anticipations of an ecological disaster on a global scale associated with environmental pollution. Solution of these problems on a global scale is based on a sustainable development strategy. The sustainable development is a balance between natural environment (biosphere) and artificial environment (technosphere). Russian thinkers of the early XX century introduced a notion of noosphere. One of (...) the landmarks of sustainable developmentmust become ecosophy. Asian civilization has been developing in the spirit of ecosophy. It shows that one can live in equilibrium with natural surroundings and scientific progress, preserving spiritual culture and maintaining high spiritual standard. Extending of culture dialogue became more essential in XXI century. (shrink)

The purpose of the study is to characterize the reproductive capabilities of human capital at the regional level. The article presents the results of a study concerning the state of factors determining the reproduction of human capital in the conditions of digitalization. The analysis of each of the indicators characterizing the reproductive capabilities of the human capital of the region is carried out. Special attention is paid to the quantitative and qualitative characteristics of the factors of reproduction of human capital, (...) as well as the role of the state in solving social problems of the region. (shrink)

The research sets out an organizing framework for the field of social ontology, the study of the of the nature of the social world. Social ontology is also gaining prominence in traditional philosophical discussions. The subject matter of social ontology is clarified, in particular the difference between it and the study of causal relations and the explanation of social phenomena. For any social fact, there are two distinct ontological questions: what is the ground for that fact, why is that fact (...) grounded just the way. Two different inquires are defined and explained: the study of how social categories are “anchored” or “grounded”. The distinction between these inquires is used to clarify prominent programs in social theory, particularly theories of practice and varieties of ontological individualism. Anchoring and grounding are two fundamental aspect to the building of the social world, Correspondingly, social ontology consists of two distinct project - “project of grounding” and “project of anchoring’. (shrink)

High‐precision tumor targeting with conventional therapeutics is based on the concept of the ideal drug as a “magic bullet”; this became possible after techniques were developed for production of monoclonal antibodies (mAbs). Innovative DNA technologies have revolutionized this area and enhanced clinical efficiency of mAbs. The experience of applying small‐size recombinant antibodies (monovalent binding fragments and their derivatives) to cancer targeting showed that even high‐affinity monovalent interactions provide fast blood clearance but only modest retention time on the target antigen. Conversion (...) of recombinant antibodies into multivalent format increases their functional affinity, decreases dissociation rates for cell‐surface and optimizes biodistribution. In addition, it allows the creation of bispecific antibody molecules that can target two different antigens simultaneously and do not exist in nature. Different multimerization strategies used now in antibody engineering make it possible to optimize biodistribution and tumor targeting of recombinant antibody constructs for cancer diagnostics and therapy. BioEssays 30:904–918, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

This book develops a general analysis and synthesis framework for impulsive and hybrid dynamical systems.

This book places thermodynamics on a system-theoretic foundation so as to harmonize it with classical mechanics. Using the highest standards of exposition and rigor, the authors develop a novel formulation of thermodynamics that can be viewed as a moderate-sized system theory as compared to statistical thermodynamics. This middle-ground theory involves deterministic large-scale dynamical system models that bridge the gap between classical and statistical thermodynamics. The authors' theory is motivated by the fact that a discipline as cardinal as thermodynamics--entrusted with some (...) of the most perplexing secrets of our universe--demands far more than physical mathematics as its underpinning. Even though many great physicists, such as Archimedes, Newton, and Lagrange, have humbled us with their mathematically seamless eurekas over the centuries, this book suggests that a great many physicists and engineers who have developed the theory of thermodynamics seem to have forgotten that mathematics, when used rigorously, is the irrefutable pathway to truth. This book uses system theoretic ideas to bring coherence, clarity, and precision to an extremely important and poorly understood classical area of science. (shrink)

Individuals with Down syndrome (DS) are widely believed to possess considerable socialization strengths. However, the findings on social cognition capabilities are controversial. In the present study, we investigated whether individuals with DS exhibit shortage in face tuning, one of the indispensable components of social cognition. For this purpose, we implemented a recently developed Face-n-Food paradigm with food-plate images composed of food ingredients such as fruits and vegetables. The key benefit of such ‘face like non-face’ images is that single elements do (...) not facilitate face processing. In a spontaneous recognition task, 25 children with DS aged 9 to 18 years were presented with a set of Face-n-Food images bordering on the Giuseppe Arcimboldo style. The set of images was administered in a predetermined order from the least to most resembling a face. In DS individuals, thresholds for recognition of the Face-n-Food images as a face were drastically higher as compared not only with typically developing controls, but also with individuals with autistic spectrum disorders and Williams-Beuren syndrome. This outcome represents a significant step towards better conceptualization of visual social world in DS and neurodevelopmental disorders in general. (shrink)

Kant’s transcendental philosophy of Kant is the metaphysics of possible experience related to the solution of the [semantic] problem set in his famous letter to M. Hertz (02.21.1772): “What is the ground of the relation of that in us which we call 'representation' to the object?” There are two possible ways to solve it: empiricism and apriorism, – and Kant chooses the second of them, thus making his “Copernican Revolution”. In the Preface to the 2nd ed. Critique Kant correlates his (...) Copernican turn/revolution with "altered method of our way of thinking [in metaphysics]" [BXVIII] and considers it as an analogue of the hypothetico-deductive scientific method of Copernicus – Galileo – Newton. The analysis of structure of the Copernican Revolution shows that it is possible to pick out two vectors: the empirical (from the thing-in-itself to representations) and the noumenal ones (from the transcendental unity of apperception [or transcendental object] to objects of experience). The introduction of an a priori vector (resp. a priori forms) means that Kant's conception is not empirical, but Kant’s keeping empirical vector says that it is compatible with empirical realism [A370–1]. Thus, Kantian transcendentalism is a synthesis of realism (basic level) and transcendental idealism (as a meta-level superstructure above it), whose task is to find out and analyze the transcendental conditions [possibility] of our knowledge of objects. (shrink)

The philosophical definition of violence today is?incomplete? and leaves a?gap? between the phenomenon and the concept. This is due to the fact that the concept of?violence? was/is strangely included in the general philosophical categorial line. In domestic and Western discourse, the problem field of violence contains, above all, political and ethical meanings. The problem is intuitively resolved in its appeal to the concept of?power?, which turns out to be philosophically lost in modern philosophy. Only exceptionally do we find?traces? of this (...) concept in philosophical works. Among them are the works of Aristotle, which need to be freed from modern, distorting interpretations. Thus, in the translations of Aristotle, the Greek???????, used for the traditional transferring the category of possibility, lost its meaning of force ; in its turn,?force? lost relation to?violence? and?necessity?. Violence is understood as a kind of necessity, which is associated with the suppression of one?s?own decision?, freedom, something that?prevents desire? and contrary to?common thinking,? as well as the absence of?good?. Violence is presented not only in an ontological sense, but also existentially, as the opposite of?good? and of one?s own?desire?. Force remains in the shadow of?necessity? as?possibility?,?potential energy? and?movement?, and violence loses the opposition that has arisen in an ontological mode. nema. (shrink)

Fyodor M. Dostoevsky’s analysis of the theme of Russia–Europe relations, as well as the nature of Russian society, is replete with concept-metaphors like “people,” “national principle,” “soul,” “sp...

The philosophical definition of violence today is “incomplete” and leaves a “gap” between the phenomenon and the concept. This is due to the fact that the concept of “violence” was/is strangely included in the general philosophical categorial line. In domestic and Western discourse, the problem field of violence contains, above all, political and ethical meanings. The problem is intuitively resolved in its appeal to the concept of “power”, which turns out to be philosophically lost in modern philosophy. Only exceptionally do (...) we find “traces” of this concept in philosophical works. Among them are the works of Aristotle, which need to be freed from modern, distorting interpretations. Thus, in the translations of Aristotle, the Greek δύναμις, used for the traditional transferring the category of possibility, lost its meaning of force ; in its turn, “force” lost relation to “violence” and “necessity”. Violence is understood as a kind of necessity, which is associated with the suppression of one’s “own decision”, freedom, something that “prevents desire” and contrary to “common thinking,” as well as the absence of “good”. Violence is presented not only in an ontological sense, but also existentially, as the opposite of “good” and of one’s own “desire”. Force remains in the shadow of “necessity” as “possibility”, “potential energy” and “movement”, and violence loses the opposition that has arisen in an ontological mode. (shrink)

The article is a philosophical reflection of the author, caused by M.N. Epstein’s book “Children’s Questions: Dialogues” (Moscow, 2020). The book presents more than 300 children’s questions, covering the most diverse facets of being: from the universe as a whole to psychological, moral, social, aesthetic problems. The idea of the book is to engage children and adults in a general conversation about the most important phenomena of the universe. The author of the article weaves the material of the book into (...) the outline of existential comprehension of truth. (shrink)

The article is a philosophical essay based on Maria Tillmanns’ book Why We Are in Need of Tails (Iguana Books, 2019). In an allegorical form the essay presents many current philosophical issues such as understanding, companionship, communication, attitude towards the Other, and the continuity of cultural tradition.

The early decades of the last century saw European philosophical thought becoming increasingly interested in the sociological extension of the idea of law. From the viewpoint of the sociology of law, law is formed in the process of social interactions and is not sanctioned by the state. Sergey Hessen and Georges Gurvitch base their conceptions of social law on the sociology of law in the 1920s and 1930s. They start a polemic in the pages of the journal Sovremenniye zapiski. (...) Although they differ radically in their definitions of the status of the state they concur in defining society as a set of social institutions and communities existing as instruments for expressing personal freedom. The social regulations they propose are already legal situations. Hessen and Gurvitch believe that the individual can fully exercise his/her freedom only in conditions of such legal pluralism. However, the concept of legal pluralism involves an inherent problem of preserving social unity: why is it that society does not fall into a range of autonomous social entities, each offering the individual its own legal order for actualising freedom? To solve this problem the philosophers use the concept of “the general will”. General will is an instrument of correlation between individual freedom and the development of society and culture as a whole. The object of philosophical dispute is how the general will is formed: 1) in the process of social self-organisation according to Gurvitch; 2) in the operation of the suprafunctional organisation according to Hessen. The difference in the grounding of the general will leads to a difference in the concepts of social unity: 1) sobornost according to Gurvitch and 2) solidarity according to Hessen. Analysis of the dispute between Gurvitch and Hessen brings out not only the differences in the interpretation of social unity but also the fundamental problems with the conceptions of social law. (shrink)

In recent decades, perspectivism has developed into an epistemological research program claiming its independence. This autonomy stems from Perspectivism’s potential ability to resolve the contradictions between realist and constructivist programs. Perspectivism is based on the idea that the object depends on perspective, which constitutes any subjective attempt to cognize it. Perspectivists reconstruct and explain the factors involved in the formation of perspective, identifying the conditionality of epistemic acts, using concepts such as “position”, “point of view”, “view”, “angle”, “horizon”, “focus”, “picture”, (...) “context”, “aspect”, etc. Although these concepts are part of the perspectivist’s toolkit, their meanings and interrelation have so far been taken for granted and have not yet been critically and comprehensively analyzed. The purpose of this article is to take steps toward clarifying the conceptual basis for defending perspectivism as an epistemological program. Once consistently uncovered and correlated in a conceptual model, Perspectivist concepts can be used as a tool for a detailed analysis of theories, positions, and beliefs. The article begins with a preliminary description of the concept of perspectivism and its brief history as an epistemological program. In particular, the first modern attempts to outline perspectivist epistemology are described in the works of F. Kaulbach (1990), W. Stegmaier (2008), and M. Massimi (2017, 2020). The problem of identifying the special a priori status of perspectivist notions as a strategy for justifying the autonomy of Perspectivism is then posed. A method for demonstrating such a status, based on Kant’s transcendentalism and P. Strawson’s descriptive metaphysics, is then suggested. (shrink)

Philosophical Thought in Russia in the Second Half of the 20th Century is the first book of its kind that offers a systematic overview of an often misrepresented period in Russia's philosophy. Focusing on philosophical ideas produced during the late 1950s – early 1990s, it reconstructs the development of genuine philosophical thought in the Soviet period and introduces those non-dogmatic Russian thinkers who saw in philosophy a means of reforming social and intellectual life. Covering such areas of philosophical inquiry as (...) philosophy of science, philosophical anthropology, the history of philosophy, activity approach as well as communication and dialogue studies, the volume presents and thoroughly discusses central topics and concepts developed by Soviet thinkers in that particular fields. Written by a team of internationally recognized scholars from Russia and abroad, it examines the work of well-known Soviet philosophers (such as Mikhail Bakhtin, Evald Ilyenkov and Merab Mamardashvili) as well as those important figures (such as Vladimir Bibler, Alexander Zinoviev, Yury Lotman, Georgy Shchedrovitsky, Genrich Batishchev, Sergey Rubinstein, and others) who have often been overlooked. By introducing and examining original philosophical ideas that evolved in the Soviet period, the book confirms that not all Soviet philosophy was dogmatic and tied to orthodox Marxism and the ideology of Marxism-Leninism. It shows Russian philosophical development of the Soviet period in a new light, as a philosophy defined by a genuine discourse of exploration and intellectual progress, rather than stagnation and dogmatism. In addition to providing the historical and cultural background that explains the development of the 20th-century Russian philosophy, the book also puts the discussed ideas and theories in the context of contemporary philosophical discussions showing their relevance to nowadays debates in Western philosophy. With short biographies of key thinkers, an extensive current bibliography and a detailed chronology of Soviet philosophy, this research resource provides a new understanding of the Soviet period and its intellectual legacy 100 years after the Russian Revolution. (shrink)

This paper examines the efforts of two young Russian chemists during the late 1850s and early 1860s to establish a professional chemistry journal and a public laboratory for chemistry research in Russia. These two, N. N. Sokolov and A. N. Engel' gardt, were important participants in the early efforts to institutionalize and professionalize chemistry in Russia. However, both the chemistry laboratory and the chemistry journal ended after only a few years. The chemistry journal was curtailed not because of Government (...) interference, as is sometimes asserted, but because of a conflict over editorial policy and independence. The chemistry laboratory was closed and the equipment donated to St Petersburg University when Sokolov was appointed to the position of adjunct there. (shrink)

Machine generated contents note: List of contributors; Acknowledgments; Introduction: the humanist tradition in Russian philosophy G. M. Hamburg and Randall A. Poole; Part I. The Nineteenth Century: 1. Slavophiles, Westernizers, and the birth of Russian philosophical humanism Sergey Horujy; 2. Alexander Herzen Derek Offord; 3. Materialism and the radical intelligentsia: the 1860s Victoria S. Frede; 4. Russian ethical humanism: from populism to neo-idealism Thomas Nemeth; Part II. Russian Metaphysical Idealism in Defense of Human Dignity: 5. Boris Chicherin and human (...) dignity in history G. M. Hamburg; 6. Vladimir Solov'iev's philosophical anthropology: autonomy, dignity, perfectibility Randall A. Poole; 7. Russian panpsychism: Kozlov, Lopatin, Losskii James P. Scanlan; Part III. Humanity and Divinity in Russian Religious Philosophy after Solov'iev: 8. A Russian cosmodicy: Sergei Bulgakov's religious philosophy Paul Valliere; 9. Pavel Florenskii's trinitarian humanism Steven Cassedy; 10. Semën Frank's expressivist humanism Philip J. Swoboda; Part IV. Freedom and Human Perfectibility in the Silver Age: 11. Religious humanism in the Russian silver age Bernice Glatzer Rosenthal; 12. Russian liberalism and the philosophy of law Frances Nethercott; 13. Imagination and ideology in the new religious consciousness Robert Bird; 14. Eschatology and hope in silver age thought Judith Deutsch Kornblatt; Part V. Russian Philosophy in Revolution and Exile: 15. Russian Marxism Andrzej Walicki; 16. Adventures in dialectic and intuition: Shpet, Il'in, Losev Philip T. Grier; 17. Nikolai Berdiaev and the philosophical tasks of the emigration Stuart Finkel; 18. Eurasianism: affirming the person in an 'Era of Faith' Martin Beisswenger; Afterword: on persons as open-ended ends-in-themselves (the view from two novelists and two critics) Caryl Emerson; Bibliography. (shrink)

The European Legacy, Volume 17, Issue 4, Page 548-549, July 2012.

Les notions d'ordre, de raison, de conscience sont des concepts de la philosophie de Rousseau et, en même temps, les valeurs de sa vie. L'idéal de la société constitue un cadre de réflexions sur ces valeurs, exprimant son identité d'écrivain dans la vie sociale et intellectuelle de son temps. Ainsi, il s'écarte de l'utopie au sens propre du mot.

The content of the activity of the pupils in our experimental recreation centers of socialization and the specifics of the activities of educators are given. The specifics of the view on the subjects of socio-pedagogical work is shown.

This study described the relationships between academic class and student moral sensitivity and reasoning and between curriculum design components for ethics education and student moral sensitivity and reasoning. The data were collected from freshman (n = 506) and senior students (n = 440) in eight baccalaureate nursing programs in South Korea by survey; the survey consisted of the Korean Moral Sensitivity Questionnaire and the Korean Defining Issues Test. The results showed that moral sensitivity scores in patient-oriented care and conflict were (...) higher in senior students than in freshman students. Furthermore, more hours of ethics content were associated with higher principled thinking scores of senior students. Nursing education in South Korea may have an impact on developing student moral sensitivity. Planned ethics content in nursing curricula is necessary to improve moral sensitivity and moral reasoning of students. (shrink)

The specificity of eukaryotic DNA organization into loops fixed to the nuclear matrix/chromosomal scaffold has been studied for more than fifteen years. The results and conclusions of different authors remain, however, controversial. Recently, we have elaborated a new approach to the study of chromosomal DNA loops. Instead of characterizing loop basements (nuclear matrix DNA), we have concentrated our efforts on the characterization of individual loops after their excision by DNA topoisomerase II‐mediated DNA cleavage at matrix attachment sites. In this review (...) the results of applying this mapping approach are compared with the results and conclusions from studies of nuclear matrix DNA. An attempt is also made to reconsider all data about the specificity of DNA interactions with the nuclear matrix and to suggest a model of spatial organization of the eukaryotic genome which resolves apparent contradictions between these data. (shrink)

This text explores how human beings construe experience: experience as a resource, as a potential for understanding, representing and acting on reality.

We exploit properties of certain directed graphs, obtained from the families of sets with special effective enumeration properties, to generalize several results in computable model theory to higher levels of the hyperarithmetical hierarchy. Families of sets with such enumeration features were previously built by Selivanov, Goncharov, and Wehner. For a computable successor ordinal α, we transform a countable directed graph into a structure such that has a isomorphic copy if and only if has a computable isomorphic copy.A computable structure is (...) categorical if for all computable isomorphic copies of , there is an isomorphism from onto , which is . We prove that for every computable successor ordinal α, there is a computable, categorical structure, which is not relatively categorical. This generalizes the result of Goncharov that there is a computable, computably categorical structure, which is not relatively computably categorical.An additional relation R on the domain of a computable structure is intrinsically on if in all computable isomorphic copies of , the image of R is . We prove that for every computable successor ordinal α, there is an intrinsically relation on a computable structure, which not relatively intrinsically . This generalizes the result of Manasse that there is an intrinsically computably enumerable relation on a computable structure, which is not relatively intrinsically computably enumerable.The dimension of a structure is the number of computable isomorphic copies, up to isomorphisms. We prove that for every computable successor ordinal α and every n≥1, there is a computable structure with dimension n. This generalizes the result of Goncharov that there is a structure of computable dimension n for every n≥1.Finally, we prove that for every computable successor ordinal α, there is a countable structure with isomorphic copies in just the Turing degrees of sets X such that relative to X is not . In particular, for every finite n, there is a structure with isomorphic copies in exactly the non- Turing degrees. This generalizes the result obtained by Wehner, and independently by Slaman, that there is a structure with isomorphic copies in exactly the nonzero Turing degrees. (shrink)

The belief in the Darwinian theory of evolution appeared to be shaken when one tried to interpret statements of molecular biology in it. As a consequence there arose a theory of non-Darwinian neutral evolution. The supporters of this theory believe that under natural conditions no factors exist which can distinguish and select organisms on their internal (molecular) structure. In the opinion of these neutralists natural selection cannot in principle control the molecular constitution of organisms. Contrary to the viewpoint of the (...) critics of neutralism it is impossible to admit that nucleic acids, proteins and other biomolecules can evolve without the participation of natural selection. This controversy in contemporary theoretical biology can be solved by integrating the conceptions of molecular ecology with Darwinian theory. Molecular ecology acknowledges the interactions of organisms by means of chemical substances synthesized by them. Such chemical ecological factors play a leading part in the selective stages of biomolecular evolution. These diverse chemical ecological interrelations take place intensively when living beings interact with parasitic microbes. (shrink)

The article discusses the importance of strength training in the training process and its impact on the technical skills of athletes. The use of strength exercises during training sessions and rational planning of strength training in the training process are considered. Practical and methodological recommendations are given on the use of various strength physical exercises to improve the technique of basic competitive movements. Examples of the use of various physical loads during certain exercises in order to improve the technical readiness (...) of athletes are shown. (shrink)

We study semi-isolation as a binary relation on the locus of a complete type and prove that—under some additional assumptions—it induces the strict order property.